Oxidation of Acetaminophen

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acetaminophen

Current HRP/H2O2/APAP Radical Data

New data

HRP/H2O2

Free-Radical Metabolites of Acetaminophen and a Dimethylated Derivative
Volker Fischer, Paul R. West, Laura S. Harman, and Ronald P. Mason.
Environmental Health Perspectives, 1985, 64, pp. 127-137.
here
ACETAMINOPHEN - ENZYMATIC FORMATION OF A TRANSIENT PHENOXYL FREE-RADICAL
West, PR, Harman, LS, Josephy, PD, Mason, RP
Biochemical pharmacology , 1984, Vol.33(18), pp.2933-2936
here
West 1984
Direct electron spin resonance detection of free radical intermediates during the peroxidase catalyzed oxidation of phenacetin metabolites.
Volker Fischer, Laura S. Harman, Paul R. West, and Ronald P. Mason.

"Chem.-Biol. Interactions, 1986, Vol 60, PP. 115-127.

HRP/H2O2/Acetaminophen analog

Stable Free Radical and Benzoquinone Imine Metabolites of an Acetaminophen Analogue
Volker Fischer and Ronald P. Mason.
Journal of Biological Chemistry, 1984, 259(16), pp. 10284-10288.
here
Fischer, 1984
Fischer, 1984

with GSH

Media:J. Biol. Chem.-1990-Ramakrishna Rao-844-7.pdf

Oxidation Product Analysis

Identification of Acetaminophen Polymerization Products Catalyzed by Horseradish Peroxidase.
David W. Potter$, Dwight W. Miller, and Jack A. Hinson
Journal of Biological Chemistry, 1985 "260(22), pp 12174-12180.
here
Fischer, 1984

Related Phenacetin

http://www.ncbi.nlm.nih.gov/pubmed/3024853