Difference between revisions of "Ian Salveson Chem430 S17"
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Revision as of 19:08, 3 February 2017
Chemistry/Biochemistry Research 430
- Spring 2017
- Ian Salveson
- Senior Chemistry Major
Research Times
Mon: 10AM-12PM + 6-8PM
Proposed Research Project
Investigating the metabolism of acetaminophen modeled by an enzymatic, single-electron oxidation using HRP and to investigate the chemical properties of the primary products.
Project Title
Characterization and Analysis of Acetaminophen Metabolites
General Information
- Advisor: Dr. Bradley E. Sturgeon
Proposal
Determine chemical properties of previously isolated primary acetaminophen oxidation products using cyclic voltammetry and ESR spectroscopy.
Instruments to be used
HPLC, Flash Chromotography System, NMR, Immobilized Enzyme column, ESR
References (2 minimum)
1.) Hinson, Jack A., Dean W. Roberts, and Laura P. James. "Mechanisms of Acetaminophen-Induced Liver Necrosis." Handbook of Experimental Pharmacology Adverse Drug Reactions (2009): 369-405. Web. 2.) Potter, David W., Dwight W. Miller, and Jack A. Hinson. "Identification of Acetaminophen Polymerization Products Catalyzed by Horseradish Peroxidase." Journal of Biological Chemistry 260.22 (1985): 12174-2180. Print.
Research pledge
I, Ian Salveson, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.