Ian Salveson Chem430 S17

Chemistry/Biochemistry Research 430

Spring 2017

Ian Salveson

Senior Chemistry Major

Research Times

Mon: 10AM-12PM + 6-8PM

       Meeting Time: Wed. 11:00

Proposed Research Project

Investigating the metabolism of acetaminophen modeled by an enzymatic, single-electron oxidation using HRP and to investigate the chemical properties of the primary products.

Project Title

Characterization and Analysis of Acetaminophen Metabolites

General Information

Advisor: Dr. Bradley E. Sturgeon

Proposal

Determine chemical properties of previously isolated primary acetaminophen oxidation products using cyclic voltammetry and ESR spectroscopy.

Instruments to be used

HPLC, Flash Chromotography System, NMR, Immobilized Enzyme column, ESR

References (2 minimum)

1.) Hinson, Jack A., Dean W. Roberts, and Laura P. James. "Mechanisms of Acetaminophen-Induced Liver Necrosis." Handbook of Experimental Pharmacology Adverse Drug Reactions (2009): 369-405. Web. 2.) Potter, David W., Dwight W. Miller, and Jack A. Hinson. "Identification of Acetaminophen Polymerization Products Catalyzed by Horseradish Peroxidase." Journal of Biological Chemistry 260.22 (1985): 12174-2180. Print.

Research pledge

I, Ian Salveson, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.