Difference between revisions of "Oxidation of Acetaminophen"

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:[[File:APAP radical mason.pdf|PDF here]]
 
:[[File:APAP radical mason.pdf|PDF here]]
 
[[File:Screen Shot 2018-07-15 at 7.38.54 AM.png|200px|thumb|center|Fischer 1986]]
 
[[File:Screen Shot 2018-07-15 at 7.38.54 AM.png|200px|thumb|center|Fischer 1986]]
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|[[File:APAP rad HRP.png|200px|thumb|center|West 1984]]||[[File:Screen Shot 2018-07-15 at 7.38.54 AM.png|200px|thumb|center|Fischer 1986]]
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==HRP/H2O2/Acetaminophen analog==
 
==HRP/H2O2/Acetaminophen analog==

Revision as of 12:56, 15 July 2018

acetaminophen

Current HRP/H2O2/APAP Radical Data

New data

HRP/H2O2

Free-Radical Metabolites of Acetaminophen and a Dimethylated Derivative
Volker Fischer, Paul R. West, Laura S. Harman, and Ronald P. Mason.
Environmental Health Perspectives, 1985, 64, pp. 127-137.

PDF here

ACETAMINOPHEN - ENZYMATIC FORMATION OF A TRANSIENT PHENOXYL FREE-RADICAL
West, PR, Harman, LS, Josephy, PD, Mason, RP
Biochemical pharmacology , 1984, Vol.33(18), pp.2933-2936
PDF here
West 1984
Direct electron spin resonance detection of free radical intermediates during the peroxidase catalyzed oxidation of phenacetin metabolites.
Volker Fischer, Laura S. Harman, Paul R. West, and Ronald P. Mason.

"Chem.-Biol. Interactions, 1986, Vol 60, PP. 115-127.

File:APAP radical mason.pdf
Fischer 1986
West 1984
Fischer 1986

HRP/H2O2/Acetaminophen analog

Stable Free Radical and Benzoquinone Imine Metabolites of an Acetaminophen Analogue
Volker Fischer and Ronald P. Mason.
Journal of Biological Chemistry, 1984, 259(16), pp. 10284-10288.
here
Fischer, 1984
Fischer, 1984

with GSH

Media:J. Biol. Chem.-1990-Ramakrishna Rao-844-7.pdf

Oxidation Product Analysis

Identification of Acetaminophen Polymerization Products Catalyzed by Horseradish Peroxidase.
David W. Potter$, Dwight W. Miller, and Jack A. Hinson
Journal of Biological Chemistry, 1985 "260(22), pp 12174-12180.
here
Fischer, 1984

Related Phenacetin

http://www.ncbi.nlm.nih.gov/pubmed/3024853