Difference between revisions of "Oxidation of Acetaminophen"
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| Line 12: | Line 12: | ||
|Spectrum ||unresolved triplet||high res multiline||med res multiline | |Spectrum ||unresolved triplet||high res multiline||med res multiline | ||
|- | |- | ||
| − | | N (1) || nr|| 0.81 G ||1.68 G | + | | N (1) || align=center|nr|| 0.81 G ||1.68 G |
|- | |- | ||
| H, on nitrogen (1) || nr || 1.35 G ||0.96 G | | H, on nitrogen (1) || nr || 1.35 G ||0.96 G | ||
Revision as of 15:22, 15 July 2018
Summary of ESR Data
| Nucle (# of spins)i | hyperfine | hyperfine | hyperfine |
|---|---|---|---|
| Ref --> | West, 1984 | Fischer, 1986 | Sturgeon, not published |
| Conditions | Fast-Flow, pH 7.5 | Fast-flow, pH 7.5 | Immobl-Enzyme, pH 5/dioxane |
| Spectrum | unresolved triplet | high res multiline | med res multiline |
| N (1) | nr | 0.81 G | 1.68 G |
| H, on nitrogen (1) | nr | 1.35 G | 0.96 G |
| H, ortho (2) | 5.2 G | 5.11 G | 5.19 G |
| H, meta (2) | nr | 0.64 G | 0.76 G |
| H, methyl (3) | nr | 1.01 G | nr |
nr = not reported or not resolved
HRP/H2O2
- ACETAMINOPHEN - ENZYMATIC FORMATION OF A TRANSIENT PHENOXYL FREE-RADICAL
- West, PR, Harman, LS, Josephy, PD, Mason, RP
- Biochemical pharmacology, 1984, Vol.33(18), pp.2933-2936.
- Free-Radical Metabolites of Acetaminophen and a Dimethylated Derivative
- Volker Fischer, Paul R. West, Laura S. Harman, and Ronald P. Mason.
- Environmental Health Perspectives, 1985, 64, pp. 127-137.
- Direct electron spin resonance detection of free radical intermediates during the peroxidase catalyzed oxidation of phenacetin metabolites.
- Volker Fischer, Laura S. Harman, Paul R. West, and Ronald P. Mason.
- Chem.-Biol. Interactions, 1986, Vol 60, PP. 115-127.
HRP/H2O2/Acetaminophen analog
- Stable Free Radical and Benzoquinone Imine Metabolites of an Acetaminophen Analogue
- Volker Fischer and Ronald P. Mason.
- Journal of Biological Chemistry, 1984, 259(16), pp. 10284-10288.
- here
with GSH
Oxidation Product Analysis
- Identification of Acetaminophen Polymerization Products Catalyzed by Horseradish Peroxidase.
- David W. Potter$, Dwight W. Miller, and Jack A. Hinson
- Journal of Biological Chemistry, 1985 "260(22), pp 12174-12180.
- here
