Difference between revisions of "Oxidation of Acetaminophen"
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==HRP/H2O2== | ==HRP/H2O2== | ||
{| | {| | ||
| − | |[[File:APAP rad HRP.png|200px|thumb|center|West 1984, Fischer, | + | |[[File:APAP rad HRP.png|200px|thumb|center|West 1984, Fischer,1985]]||[[File:Screen Shot 2018-07-15 at 7.38.54 AM.png|230px|thumb|center|Fischer 1986]] |
|} | |} | ||
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| + | :'''ACETAMINOPHEN - ENZYMATIC FORMATION OF A TRANSIENT PHENOXYL FREE-RADICAL''' | ||
| + | :West, PR, Harman, LS, Josephy, PD, Mason, RP | ||
| + | :[[Media:West 1984.pdf|''Biochemical pharmacology'', '''1984''', ''Vol.33(18)'', pp.2933-2936.]] | ||
:'''Free-Radical Metabolites of Acetaminophen and a Dimethylated Derivative''' | :'''Free-Radical Metabolites of Acetaminophen and a Dimethylated Derivative''' | ||
:Volker Fischer, Paul R. West, Laura S. Harman, and Ronald P. Mason. | :Volker Fischer, Paul R. West, Laura S. Harman, and Ronald P. Mason. | ||
:[[Media:Envhper00447-0129.pdf|''Environmental Health Perspectives'', '''1985''', ''64'', pp. 127-137.]] | :[[Media:Envhper00447-0129.pdf|''Environmental Health Perspectives'', '''1985''', ''64'', pp. 127-137.]] | ||
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:'''Direct electron spin resonance detection of free radical intermediates during the peroxidase catalyzed oxidation of phenacetin metabolites.''' | :'''Direct electron spin resonance detection of free radical intermediates during the peroxidase catalyzed oxidation of phenacetin metabolites.''' | ||
Revision as of 14:59, 15 July 2018
Current HRP/H2O2/APAP Radical Data
| Nuclei | hyperfine (number spins) |
|---|---|
| Ref --> | Mason |
| N | 0.81 G (1) |
| H, on nitrogen | 1.35 G (1) |
| H, ortho | 5.11 G (1) |
| H, meta | 0.64 G (1) |
| H, methoxy | 1.01 (3) |
HRP/H2O2
- ACETAMINOPHEN - ENZYMATIC FORMATION OF A TRANSIENT PHENOXYL FREE-RADICAL
- West, PR, Harman, LS, Josephy, PD, Mason, RP
- Biochemical pharmacology, 1984, Vol.33(18), pp.2933-2936.
- Free-Radical Metabolites of Acetaminophen and a Dimethylated Derivative
- Volker Fischer, Paul R. West, Laura S. Harman, and Ronald P. Mason.
- Environmental Health Perspectives, 1985, 64, pp. 127-137.
- Direct electron spin resonance detection of free radical intermediates during the peroxidase catalyzed oxidation of phenacetin metabolites.
- Volker Fischer, Laura S. Harman, Paul R. West, and Ronald P. Mason.
- Chem.-Biol. Interactions, 1986, Vol 60, PP. 115-127.
HRP/H2O2/Acetaminophen analog
- Stable Free Radical and Benzoquinone Imine Metabolites of an Acetaminophen Analogue
- Volker Fischer and Ronald P. Mason.
- Journal of Biological Chemistry, 1984, 259(16), pp. 10284-10288.
- here
with GSH
Oxidation Product Analysis
- Identification of Acetaminophen Polymerization Products Catalyzed by Horseradish Peroxidase.
- David W. Potter$, Dwight W. Miller, and Jack A. Hinson
- Journal of Biological Chemistry, 1985 "260(22), pp 12174-12180.
- here
