Difference between revisions of "Oxidation of Acetaminophen"

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==HRP/H2O2==
 
==HRP/H2O2==
 
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{|
|[[File:APAP rad HRP.png|200px|thumb|center|West 1984, Fischer,1986]]||[[File:Screen Shot 2018-07-15 at 7.38.54 AM.png|230px|thumb|center|Fischer 1986]]
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|[[File:APAP rad HRP.png|200px|thumb|center|West 1984, Fischer,1985]]||[[File:Screen Shot 2018-07-15 at 7.38.54 AM.png|230px|thumb|center|Fischer 1986]]
 
|}
 
|}
 +
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:'''ACETAMINOPHEN - ENZYMATIC FORMATION OF A TRANSIENT PHENOXYL FREE-RADICAL'''
 +
:West, PR, Harman, LS, Josephy, PD, Mason, RP
 +
:[[Media:West 1984.pdf|''Biochemical pharmacology'', '''1984''', ''Vol.33(18)'', pp.2933-2936.]]
  
 
:'''Free-Radical Metabolites of Acetaminophen and a Dimethylated Derivative'''
 
:'''Free-Radical Metabolites of Acetaminophen and a Dimethylated Derivative'''
 
:Volker Fischer, Paul R. West, Laura S. Harman, and Ronald P. Mason.
 
:Volker Fischer, Paul R. West, Laura S. Harman, and Ronald P. Mason.
 
:[[Media:Envhper00447-0129.pdf|''Environmental Health Perspectives'', '''1985''', ''64'', pp. 127-137.]]
 
:[[Media:Envhper00447-0129.pdf|''Environmental Health Perspectives'', '''1985''', ''64'', pp. 127-137.]]
 
:'''ACETAMINOPHEN - ENZYMATIC FORMATION OF A TRANSIENT PHENOXYL FREE-RADICAL'''
 
:West, PR, Harman, LS, Josephy, PD, Mason, RP
 
:[[Media:West 1984.pdf|''Biochemical pharmacology'', '''1984''', ''Vol.33(18)'', pp.2933-2936.]]
 
  
 
:'''Direct electron spin resonance detection of free radical intermediates during the peroxidase catalyzed oxidation of phenacetin metabolites.'''
 
:'''Direct electron spin resonance detection of free radical intermediates during the peroxidase catalyzed oxidation of phenacetin metabolites.'''

Revision as of 14:59, 15 July 2018

acetaminophen

Current HRP/H2O2/APAP Radical Data

New data
Summary of Hyperfine Coupling
Nuclei hyperfine (number spins)
Ref --> Mason
N 0.81 G (1)
H, on nitrogen 1.35 G (1)
H, ortho 5.11 G (1)
H, meta 0.64 G (1)
H, methoxy 1.01 (3)

HRP/H2O2

West 1984, Fischer,1985
Fischer 1986
ACETAMINOPHEN - ENZYMATIC FORMATION OF A TRANSIENT PHENOXYL FREE-RADICAL
West, PR, Harman, LS, Josephy, PD, Mason, RP
Biochemical pharmacology, 1984, Vol.33(18), pp.2933-2936.
Free-Radical Metabolites of Acetaminophen and a Dimethylated Derivative
Volker Fischer, Paul R. West, Laura S. Harman, and Ronald P. Mason.
Environmental Health Perspectives, 1985, 64, pp. 127-137.
Direct electron spin resonance detection of free radical intermediates during the peroxidase catalyzed oxidation of phenacetin metabolites.
Volker Fischer, Laura S. Harman, Paul R. West, and Ronald P. Mason.
Chem.-Biol. Interactions, 1986, Vol 60, PP. 115-127.

HRP/H2O2/Acetaminophen analog

Stable Free Radical and Benzoquinone Imine Metabolites of an Acetaminophen Analogue
Volker Fischer and Ronald P. Mason.
Journal of Biological Chemistry, 1984, 259(16), pp. 10284-10288.
here
Fischer, 1984
Fischer, 1984

with GSH

Media:J. Biol. Chem.-1990-Ramakrishna Rao-844-7.pdf

Oxidation Product Analysis

Identification of Acetaminophen Polymerization Products Catalyzed by Horseradish Peroxidase.
David W. Potter$, Dwight W. Miller, and Jack A. Hinson
Journal of Biological Chemistry, 1985 "260(22), pp 12174-12180.
here
Fischer, 1984

Related Phenacetin

http://www.ncbi.nlm.nih.gov/pubmed/3024853