Carley Folluo Chem430 S17

Chemistry Research 430

Spring 2017

Carley Folluo

Senior Chemistry Major

Research Times

Monday 2:30-4:00 PM Tuesday 1:00-3:30 PM

Overflow: Tuesday 3:30-5:00 PM, Thursday 12:00-2:00 PM

CHEM 430-01 = 0.25 credit = 4 hours per week.

Proposed Research Project

EPR Analysis of Neutron Irradiated Teeth

General Information

Advisor: Brad Sturgeon

Other research student collaborators: Amanda Hanks (Class of 2015)

Other Research Collaborators: University of Chicago, Dr. Fasano

Proposal

The goal of this project is to develop a method to detect radicals formed by radiation in crystalline structures via EPR. In the event of a nuclear accident, radicals produced in teeth, fingernails, and jewelry can provide means to determine the exposure of a patient for triage. Samples will be irradiated a Nordion GammaCell Co-60 Irradiation Unit at 10 cGy/s. Whole human teeth have been obtained from a local dentist, and will be placed into the gamma source. After the teeth have been irradiated, the teeth will be analyzed via EPR at 410 G. The resultant signal will produce an amplitude which is linearly proportional to the dose administered.

Instruments to be used

Electron Paramagnetic Resonance (EPR)

Nordion GammaCell Co-60 Irradiation Unit

References (2 minimum)

http://www.dartmouth.edu/~eprctr/

http://www.dartmouth.edu/~eprctr/research/tooth_dosimetry.shtml

Barr, D., Sandra S. Eaton, & Gareth R. Eaton. (2008). Workshop on Quantitative EPR. Presented at the 31st Annual International EPR Symposium, Breckenridge, Colorado.

Randall, D. W., Sturgeon, B. E., Ball, J. A., Lorigan, G. A., Chan, M. K., Klein, M. P., … Britt, R. D. (1995). 55Mn ESE-ENDOR of a Mixed Valence Mn(III)Mn(IV) Complex: Comparison with the Mn Cluster of the Photosynthetic Oxygen-Evolving Complex. Journal of the American Chemical Society, 117(47), 11780–11789.

Sturgeon, B. E., Ball, J. A., Randall, D. W., & Britt, R. D. (1994). 55Mn Electron Spin Echo ENDOR of Mn2+ Complexes. The Journal of Physical Chemistry, 98(49), 12871–12883.

Wilcox, D. E., He, X., Gui, J., Ruuge, A. E., Li, H., Williams, B. B., & Swartz, H. M. (2010). Dosimetry Based on EPR Spectral Analysis of Fingernail Clippings. Health Physics, 98(2), 309. http://doi.org/10.1097/HP.0b013e3181b27502

Williams, B. B., et al. (2010). Development of in vivo tooth EPR for individual radiation dose estimation and screening. Health Physics, 98(2), 327–338.

Zdravkova, M., et al. (2003). Retrospective Dosimetry after Criticality Accidents Using Low-Frequency EPR: A Study of Whole Human Teeth Irradiated in a Mixed Neutron and Gamma-Radiation Field. Radiation Research, 160(2), 168-173.

Research pledge

I, Carley Folluo, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.