Celestina Awopileda
Celestina's Research Page
Proposed Project Summary
Identification of Acetaminophen Free Radical Formation Products
The primary goal of this project is to identify acetaminophen free radical formation products using GC-MS. The commonly used pain killer APAP is very toxic when ingested in high doses and can result in kidney and liver damage. Cytochrome P-450 is found to be one of the two enzymes that catalyze the oxidation of APAP leading to the formation of toxic metabolites and covalent modification of proteins. This project aims to analyze these metabolites. Samples are to be prepared by acetylation of APAP polymers.