Acetaminophen

Acetaminophen, also known as paracetamol, is a painkiller and fever reducer used to treat mild to moderate pain. Acetaminophen is sold over the counter (OTC) by itself by various companies under various names with the most notable being Tylenol. The drug is also sold OTC co-formulated in many medications including cold medications, menstrual cramping medications, and various other painkillers.

APAP

History of Acetaminophen

1893- The white, odorless crystal compound is discovered at the University of Strasburg by Adolf Kussmaul and his team. used it to treat patients with naphthalene

Sources

Articles on Acetaminophen toxicity

Mechanisms of Acetaminophen-Induced Liver Necrosis

https://ccforum.biomedcentral.com/articles/10.1186/cc1475

http://onlinelibrary.wiley.com/doi/10.1002/hep.20293/full

http://www.sciencedirect.com/science/article/pii/S1544319115308475

Millions of America adults (23 percent) use acetaminophen in a given week. (Slone, JAMA 2002)

https://www.researchgate.net/profile/Paul_Whelton/publication/15230598_Perneger_TV_Whelton_PK_Klag_MJ_Risk_of_kidney_failure_associated_with_the_use_of_acetaminophen_aspirin_and_nonsteroidal_anti-inflammatory_drugs_N_Engl_J_Med_331_1675-1679/links/54a867520cf256bf8bb7e2e8/Perneger-TV-Whelton-PK-Klag-MJ-Risk-of-kidney-failure-associated-with-the-use-of-acetaminophen-aspirin-and-nonsteroidal-anti-inflammatory-drugs-N-Engl-J-Med-331-1675-1679.pdf

https://www.researchgate.net/publication/5958229_Acetaminophen_paracetamol_is_a_selective_cyclooxygenase-2_inhibitor