Brandon Allen Chem430 S17

Chemistry Research 430

Fall 2016

Brandon Allen

Sophomore Chemistry Major

Research Times

section 01 = 0.25 credit = 4 hours per week.

Proposed Research Project

Enter Project Title here

Maybe something with amyloid beta mediated oxidation of lipid membranes... Maybe antioxidant properties of some things... Most likely just playing around with Langmuir monolayer technique part 2.

General Information

Advisor: Audra Sostarecz

Other research student collaborators:

Other Research Collaborators: here

Proposal

No real research currently being conducted. Just playing around with DPPE lipid and reading articles.

Instruments to be used

Kibron Trough

References (2 minimum)

Aoki, Pedro H. B. et al. “Molecular-Level Modifications Induced by Photo-Oxidation of Lipid Monolayers Interacting with Erythrosin.” Langmuir 32.15 (2016): 3766–3773. CrossRef. Web. Faye, Ndeye Rokhaya et al. “Oxidation of Langmuir-Blodgett Films of Monounsaturated Lipids Studied by Atomic Force Microscopy.” International Journal of Nanotechnology 10.5/6/7 (2013): 390. CrossRef. Web. Hwang, Sam-Long, and Gow-Chin Yen. “Neuroprotective Effects of the Citrus Flavanones against H 2 O 2 -Induced Cytotoxicity in PC12 Cells.” Journal of Agricultural and Food Chemistry 56.3 (2008): 859–864. CrossRef. Web. Kristinová, Věra et al. “Antioxidant Activity of Phenolic Acids in Lipid Oxidation Catalyzed by Different Prooxidants.” Journal of Agricultural and Food Chemistry 57.21 (2009): 10377–10385. CrossRef. Web. Mattila, Juha-Pekka, Karen Sabatini, and Paavo K.J. Kinnunen. “Oxidized Phospholipids as Potential Novel Drug Targets.” Biophysical Journal 93.9 (2007): 3105–3112. CrossRef. Web. Murray, Ian VJ et al. “Membrane-Mediated Amyloidogenesis and the Promotion of Oxidative Lipid Damage by Amyloid β Proteins.” Journal of biological chemistry 282.13 (2007): 9335–9345. Print. Pruchnik, Hanna, Dorota Bonarska-Kujawa, and Halina Kleszczyńska. “Effect of Chlorogenic Acid on the Phase Transition in Phospholipid and Phospholipid/cholesterol Membranes.” Journal of Thermal Analysis and Calorimetry 118.2 (2014): 943–950. CrossRef. Web. Sayre, Lawrence M., George Perry, and Mark A. Smith. “Oxidative Stress and Neurotoxicity.” Chemical Research in Toxicology 21.1 (2008): 172–188. CrossRef. Web. Yoshida, Yasukazu, Aya Umeno, and Mototada Shichiri. “Lipid Peroxidation Biomarkers for Evaluating Oxidative Stress and Assessing Antioxidant Capacity in Vivo.” Journal of Clinical Biochemistry and Nutrition 52.1 (2013): 9–16. CrossRef. Web.

Research pledge

I, Brandon Allen, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.