Copasi

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Introduction

Copasi is an open source software package for modeling and simulation of biochemical reaction networks. Copasi can import and export SBML (Systems Biology Markup Language), which is a file format for exchanging models with other systems biology software.

Model Creation

  1. Click the "Model" tab from the side of the home page.
  2. Rename the model.
  3. Adjust the units according to your needs.
  4. Write any comments in the large text box
  5. Choose the biochemical tab from the side underneath the "Model" tab. Choose "Compartment" from the drop down list.
  6. Rename the compartment and and double click on the compartment.
  7. Once the compartment is adjusted to your needs, click on the "Reactions" tab.
  8. Double-Click the reaction to rename and then double-click the reaction again to put in the chemical equation. Using the equal sign means the reaction is reversible.
  9. Press the new button to create a new reaction.

Time Course Simulation

Basic Plotting

Steady State

Reports

Parameter Scanning and Sampling

Metabolic Control Analysis

References

Copasi Website