Luis Badang Chem430 F16

Chemistry/Biochemistry Research 430

Fall 2016

Luis Fred Badang

Senior Biochemistry Major

Research Times

Wed 1-5 pm

section 01 = 0.25 credit = 4 hours per week.

section 02 = 0.50 credit = 8 hours per week.

Proposed Research Project

Enter Project Title here

Mucosal Lining Interaction with Helicobacter Pylori

General Information

Advisor: Audra Sostarecz

Other research student collaborators: here

Other Research Collaborators: here

Proposal

For this semester helicobacter pylori has become a point of interest to me. When researching about this particular bacteria, I gained more knowledge on the bacteria that was the cause of my gastric and duodenal ulcer. I would like to research more on the bacteria and its effect on the mucosal lining in the stomach. First, I will begin working closely with both DPPE and DPPS to observe and collect data on the behavior of the helicobacter pylori. Later on in the research, I would like to construct an environment that resembles the stomach with a lipidbilayer that is similar to the mucosal lining. Introducing the H pylori in this environment will allow the bacteria to behave in a different way. Collection of the data will give me different curves given by the Langmuir trough to evaluate. I will be able to observe the rate at which the lipids come into order.

Instruments to be used

Langmuir trough

References (2 minimum)

Polyelectrolyte Coated Multilayered Liposomes (Nanocapsules) for the Treatment of Helicobacter pylori Infection Parul Jain, Sanyog Jain, K. N. Prasad, S. K. Jain, and Suresh P. Vyas Molecular Pharmaceutics 2009 6 (2), 593-603 DOI: 10.1021 Antimicrobial Activity of Aminoreductone against Helicobacter pylori Vu Thu Trang, Hiroaki Takeuchi, Hayato Kudo, Akitoshi Aoki, Shinya Katsuno, Tomoko Shimamura, Tetsuro Sugiura, and Hiroyuki Ukeda Journal of Agricultural and Food Chemistry 2009 57 (23), 11343-11348

Research pledge

I, Luis Fred Badang, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.