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Analysis of the Bonding Location between Cannabidiol and DOPE

Introduction

After numerous trials that investigate the interactions between phospholipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) and Cannabidiol (CBD), there have been shown to be interactions that occur that affect the packing of the phospholipid membrane formed by the DOPE molecules. These interactions affect the packing and qualities of the membrane which affects how it will acts in a true cellular membrane. An understanding of this interaction could aid in understanding the effects cannabinoids such as CBD have on biomolecules and biomolecular structures such as cellular membranes when introduced into the system. This can then be used to improve the understanding of this class of molecules as well as improve the effectiveness in pharmaceuticals.

Understanding the bonding location(s) of these two molecules will improve the understanding of the orientation of the molecules when in a system together and their overall impact on the overall system. These factors can affect crucial qualities of membranes such as fluidity.