Difference between revisions of "Hannah"

Revision as of 21:27, 15 April 2021

-may also be referred to as an alkenol

The basic reaction of keto- and enol- acetylacetone

Tautomers in DNA replication have been hypothesized to contribute to mutagenic mispairings

"whereas in RNA, minor tautomeric forms have been proposed to enhance the structural and functional diversity of RNA enzymes and aptamers" (https://rnajournal.cshlp.org/content/21/1/1.full.html)

Proton NMR

Proton NMR

N.B. Hydrogen bonding deshields the proton, further increasing the chemical shift

@@ Line 2: / Line 2: @@
 ===Tautomers of Acetylacetone (C<sub>5</sub>H<sub>8</sub>O<sub>2</sub>)===
-:-Keto = ketone
+:* Keto = ketone
-:-Enol = alcohol
+:* Enol = alcohol
 ::-may also be referred to as an alkenol
-:-Usually the keto tautomer is favored
+:* Usually the keto tautomer is favored
 [[File:tautomerism.png|thumbnail|The basic reaction of keto- and enol- acetylacetone]]
 ===Why Tautomerization Matters===
-:-Different solvents may change the equilibrium of the keto- and enol- forms
+:* Different solvents may change the equilibrium of the keto- and enol- forms
-:-Tautomers in DNA replication have been hypothesized to contribute to mutagenic mispairings
+:* Tautomers in DNA replication have been hypothesized to contribute to mutagenic mispairings
-:-"whereas in RNA, minor tautomeric forms have been proposed to enhance the structural and functional diversity of RNA enzymes and aptamers" (https://rnajournal.cshlp.org/content/21/1/1.full.html)
+:* "whereas in RNA, minor tautomeric forms have been proposed to enhance the structural and functional diversity of RNA enzymes and aptamers" (https://rnajournal.cshlp.org/content/21/1/1.full.html)
@@ Line 23: / Line 23: @@
 ==WebMO==
-:-All calculations were done using HF/6-31G(d)
+:*All calculations were done using HF/6-31G(d)
 ==Keto Acetylacetone==