Difference between revisions of "Hannah"
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Proton NMR (Hartree-Fock) | Proton NMR (Hartree-Fock) | ||
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[[File:nmrKetoZoomed.png|400px]] | [[File:nmrKetoZoomed.png|400px]] | ||
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Proton NMR (Hartree-Fock) | Proton NMR (Hartree-Fock) | ||
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[[File:nmrEnol2.png|400px]] | [[File:nmrEnol2.png|400px]] | ||
Proton NMR shifts: [[:File:NMRshifts1H-general.pdf]] | Proton NMR shifts: [[:File:NMRshifts1H-general.pdf]] | ||
Revision as of 20:32, 15 April 2021
Tautomers of Acetylacetone (C5H8O2)
Keto = ketone
Enol = alcohol
- may also be referred to as an alkenol
Usually the keto tautomer is favored
The basic reaction 
Why Tautomerization Matters
-Different solvents may change the equilibrium of the keto- and enol- forms
-Tautomers in DNA replication have been hypothesized to contribute to mutagenic mispairings
-"whereas in RNA, minor tautomeric forms have been proposed to enhance the structural and functional diversity of RNA enzymes and aptamers" (https://rnajournal.cshlp.org/content/21/1/1.full.html)
Keto Acetylacetone
.png)
Proton NMR (Hartree-Fock)
Proton NMR shifts: File:NMRshifts1H-general.pdf
Enol Acetylacetone
Proton NMR (Hartree-Fock)
Proton NMR shifts: File:NMRshifts1H-general.pdf