Difference between revisions of "Hannah"
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-Tautomers in DNA replication have been hypothesized to contribute to mutagenic mispairings | -Tautomers in DNA replication have been hypothesized to contribute to mutagenic mispairings | ||
| − | - | + | -"whereas in RNA, minor tautomeric forms have been proposed to enhance the structural and functional diversity of RNA enzymes and aptamers" (https://rnajournal.cshlp.org/content/21/1/1.full.html) |
| + | [[File:F1.large.jpg|500px]] | ||
==Keto Acetylacetone== | ==Keto Acetylacetone== | ||
Revision as of 20:23, 15 April 2021
Tautomers of Acetylacetone (C5H8O2)
Usually the keto tautomer is favored
Keto = ketone
Enol = alcohol
- may also be referred to as an alkenol
The basic reaction 
Why Tautomerization Matters
-Different solvents may change the equilibrium of the keto- and enol- forms
-Tautomers in DNA replication have been hypothesized to contribute to mutagenic mispairings
-"whereas in RNA, minor tautomeric forms have been proposed to enhance the structural and functional diversity of RNA enzymes and aptamers" (https://rnajournal.cshlp.org/content/21/1/1.full.html)
Keto Acetylacetone
With geometry optimization .png)
- PubChem's 3D structure has both oxygens pointing in the same direction (left) while NIST has the oxygens pointing in different directions (right)
- Error creating thumbnail: File missing
Proton NMR (Hartree-Fock)
Enol Acetylacetone
Proton NMR (Hartree-Fock)
