Difference between revisions of "Alex"

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==Introduction==
 
==Introduction==
  
:After numerous trials that investigate the interactions between phospholipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) and Cannabidiol (CBD), there have been shown to be interactions that occur that affect the packing of the phospholipid membrane formed by the DOPE molecules. These interactions affect the packing and qualities of the membrane which affects how it will acts in a true cellular membrane. An understanding of this interaction could aid in understanding the effects cannabinoids such as CBD have on biomolecules and biomolecular structures such as cellular membranes when introduced into the system. This can then be used to improve the understanding of this class of molecules as well as improve the effectiveness in pharmaceuticals. Understanding the bonding location(s) of these two molecules will improve the understanding of the orientation of the molecules when in a system together and their overall impact on the overall system. These factors can affect crucial qualities of membranes such as fluidity.  
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:After numerous trials that investigate the interactions that occur between DPPC and DPPE, there have been shown to be interactions that occur that affect the packing of the phospholipid membrane due to the molecules. These interactions affect the packing and qualities of the membrane which affects how it will act in a true cellular membrane. An understanding of this interaction could aid in understanding the intramembranous interactions that help to maintain the stability of the phospholipid bilayer. It is likely that the difference in interactions is due to the head group difference in these molecules which affects the way that the molecules will interact with each other when compressed.  
  
==DOPE-DOPE Interactions==
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==DPPE Head Group==
  
 
:There are two main regions associated with phospholipids, the head group, and the tail group. The head group is the hydrophilic region which is composed of numerous oxygens, a phosphate group, and other R-Groups. This region will orient towards the outside of a cell membrane. The tail group is the hydrophobic region and is composed of long hydrocarbon chains. These can be either saturated or unsaturated which are either fully bonded with hydrogens in the case of a saturated tail or have a double bond in the case of an unsaturated tail. These two regions are the main areas that inter-membraneous interactions occur between adjacent phospholipids and therefore can provide invaluable information about what is happening to a membrane when a compound, such as CBD, is introduced.  
 
:There are two main regions associated with phospholipids, the head group, and the tail group. The head group is the hydrophilic region which is composed of numerous oxygens, a phosphate group, and other R-Groups. This region will orient towards the outside of a cell membrane. The tail group is the hydrophobic region and is composed of long hydrocarbon chains. These can be either saturated or unsaturated which are either fully bonded with hydrogens in the case of a saturated tail or have a double bond in the case of an unsaturated tail. These two regions are the main areas that inter-membraneous interactions occur between adjacent phospholipids and therefore can provide invaluable information about what is happening to a membrane when a compound, such as CBD, is introduced.  
  
===Investigation of Head Group Interactions===
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===DPPC Head Group===
===Investigation of Tail Group Interactions===
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===DPPE-DPPE Head Group Interactions===
===Total Molecule Interactions===
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===DPPC-DPPC Head Group Interactions===
==CBD-DOPE Interactions==
 

Revision as of 19:22, 15 April 2021

Analysis of the Head bonding Interactions of DPPC and DPPE

Introduction

After numerous trials that investigate the interactions that occur between DPPC and DPPE, there have been shown to be interactions that occur that affect the packing of the phospholipid membrane due to the molecules. These interactions affect the packing and qualities of the membrane which affects how it will act in a true cellular membrane. An understanding of this interaction could aid in understanding the intramembranous interactions that help to maintain the stability of the phospholipid bilayer. It is likely that the difference in interactions is due to the head group difference in these molecules which affects the way that the molecules will interact with each other when compressed.

DPPE Head Group

There are two main regions associated with phospholipids, the head group, and the tail group. The head group is the hydrophilic region which is composed of numerous oxygens, a phosphate group, and other R-Groups. This region will orient towards the outside of a cell membrane. The tail group is the hydrophobic region and is composed of long hydrocarbon chains. These can be either saturated or unsaturated which are either fully bonded with hydrogens in the case of a saturated tail or have a double bond in the case of an unsaturated tail. These two regions are the main areas that inter-membraneous interactions occur between adjacent phospholipids and therefore can provide invaluable information about what is happening to a membrane when a compound, such as CBD, is introduced.

DPPC Head Group

DPPE-DPPE Head Group Interactions

DPPC-DPPC Head Group Interactions