Difference between revisions of "Investigating the Organic Synthesis of Dityrosine"
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Revision as of 22:02, 4 December 2020
You have reached the page dedicated to research investigating an efficient organic synthesis of the dityrosine molecule. This research is carried out by Monmouth College undergraduate Katelyn Richter under the supervision of Dr. Bradley Sturgeon.
Introduction
New interest in peptides and proteins containing cross-linked tyrosine residues has been on the rise due to the positive biological properties they can bring to the structures they reside in. Some examples of said biological properties include increased stabilization of structures, conformational restriction of cyclic peptides, and variation in the electronic properties seen in enzyme active sites.[1] The possibilities of application in biological systems make tyrosine dimers a molecule of great intrigue. Due to the necessary great lengths taken to isolate tyrosine and dityrosine in an industrial setting, this molecule is quite expensive. For this reason, an efficient organic synthesis pathway of dityrosine derivatives as well as their biological properties will be explored in this project.
Synthesis
Below is the synthesis pathway utilized to make dityrosine:
