Difference between revisions of "Acetaminophen Induced Toxicity"
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==Introduction== | ==Introduction== | ||
Acetaminophen (APAP) is an active ingredient in many over the counter painkillers, such as Tylenol and Oxycodone. APAP misuse is responsible for approximately 50% of acute liver failure cases in the United States (). Treatments for Acetaminophen Induced Liver Injury (AILI) are limited and ineffective if not caught early enough. Considering this and the widespread use of other prescription opioids, it is imperative that the mechanism of acetaminophen induced hepatotoxicity be revisited. | Acetaminophen (APAP) is an active ingredient in many over the counter painkillers, such as Tylenol and Oxycodone. APAP misuse is responsible for approximately 50% of acute liver failure cases in the United States (). Treatments for Acetaminophen Induced Liver Injury (AILI) are limited and ineffective if not caught early enough. Considering this and the widespread use of other prescription opioids, it is imperative that the mechanism of acetaminophen induced hepatotoxicity be revisited. | ||
| − | [[Image: | + | [[Image:APAP_two_electron_oxidation.svg|thumb|left|upright=1.2|Main pathways of paracetamol metabolism (click to enlarge). The pathway leading to NAPQI is shown in red.]] |
The current accepted mechanism by which AILI presents itself is through a two electron oxidation. | The current accepted mechanism by which AILI presents itself is through a two electron oxidation. | ||
Revision as of 21:12, 7 September 2020
Introduction
Acetaminophen (APAP) is an active ingredient in many over the counter painkillers, such as Tylenol and Oxycodone. APAP misuse is responsible for approximately 50% of acute liver failure cases in the United States (). Treatments for Acetaminophen Induced Liver Injury (AILI) are limited and ineffective if not caught early enough. Considering this and the widespread use of other prescription opioids, it is imperative that the mechanism of acetaminophen induced hepatotoxicity be revisited.
The current accepted mechanism by which AILI presents itself is through a two electron oxidation.
Materials and Methods
Results
References
Potter, David W., Dwight W. Miller, and Jack A. Hinson. Identification of Acetaminophen Polymerization Products Catalyzed by Horseradish Peroxidase. Journal of Biological Chemistry, 260,22 (1985). 12174-2180. Print