Microbiome SIBO

This is a page discussing a seminar by Dr. Mark Pimentel from Cedars-Sinai (Los Angeles, CA) in the department of Medically Associated Science and Technology (MAST) Program. Dr. Pimentel website

YouTube: SIBO, IBS & The New 3-Gas SIBO Breath Test with Dr. Mark Pimentel (March 17, 2021)

Topics discussed

Introduction

- Diagnosis of Exclusion

- IBS: Irritable Bowel Syndrome

- SIBO: Small intestinal bacteria overload

- Reference 1: Rezaie et al. Am. J. Gastroenterology (2017); unfortunately this author as multiple papers in the journal in this year...so uncertain the absolute reference.

- Reference 2: Volume and Composition of Human Intestinal Gas Determined by Means of an Intestinal Washout Technic, N. Eng. J. Med. (1971), Michael D. Levitt, M.D. Breath test to measure H₂, CO₂, and CH₄.

- Ref 3: ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth

- Ref 4: Lovell

Constipation - associated with methane/mathanogens Diarrhea - hydrogen/hydrogen sulfide

- Ref 5: Shah (2020)

- Ref 6 Gibson (1990) Strocchi (1991)

Hydrogen affects methane --> 4 H₂ -methanogens-> CH₄

Hydrogen affects hydrogen sulfide --> 5 H₂ -hydrogen sulfide producers-> H₂S

Take home point: need to measure all three gases!

- Ref 7: Poss...(2007)

- Ref 8: Ply... (2012)

- Ref 9: Ply... (2015)

E. coli and Kebsiella

Reimagine Study

- Ref 10: Reimagine Study: upper scope patients

Mapping the Segmental Microbiomes in the Human Small Bowel in Comparison with Stool: A REIMAGINE Study

Excerpt from paper:

Data availability The datasets generated during the current study are

available in the National Center for Biotechnology Information (NCBI) BioProject Repository https://www.ncbi.nlm.nih.gov/bioproject under BioProject ID PRJNA590519.