Difference between revisions of "Ian Salveson Chem430 F16"
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===Project Title=== | ===Project Title=== | ||
| − | + | Characterization and Analysis of Acetaminophen Metabolites | |
===General Information=== | ===General Information=== | ||
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HPLC, Flash Chromotography System, NMR, Immobilized Enzyme column, ESR | HPLC, Flash Chromotography System, NMR, Immobilized Enzyme column, ESR | ||
===References (2 minimum)=== | ===References (2 minimum)=== | ||
| − | 1. | + | 1.) Hinson, Jack A., Dean W. Roberts, and Laura P. James. "Mechanisms of Acetaminophen-Induced Liver Necrosis." Handbook of Experimental Pharmacology Adverse Drug Reactions (2009): 369-405. Web. |
| − | 2. | + | 2.) Potter, David W., Dwight W. Miller, and Jack A. Hinson. "Identification of Acetaminophen Polymerization Products Catalyzed by Horseradish Peroxidase." Journal of Biological Chemistry 260.22 (1985): 12174-2180. Print. |
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Latest revision as of 14:51, 28 September 2016
Chemistry/Biochemistry Research 430
- Fall 2016
- Ian Salveson
- Senior Chemistry Major
Research Times
M/W/F 10am-12pm
Proposed Research Project
Investigating the metabolism of acetaminophen modeled by an enzymatic, single-electron oxidation using HRP.
Project Title
Characterization and Analysis of Acetaminophen Metabolites
General Information
- Advisor: Dr. Bradley E. Sturgeon
Proposal
Synthesize the primary products of this oxidation and investigate their activity in a similar system to determine the level to which acetaminophen is oxidized by this type of enzyme.
Instruments to be used
HPLC, Flash Chromotography System, NMR, Immobilized Enzyme column, ESR
References (2 minimum)
1.) Hinson, Jack A., Dean W. Roberts, and Laura P. James. "Mechanisms of Acetaminophen-Induced Liver Necrosis." Handbook of Experimental Pharmacology Adverse Drug Reactions (2009): 369-405. Web. 2.) Potter, David W., Dwight W. Miller, and Jack A. Hinson. "Identification of Acetaminophen Polymerization Products Catalyzed by Horseradish Peroxidase." Journal of Biological Chemistry 260.22 (1985): 12174-2180. Print.
Research pledge
I, Ian Salveson, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.