Difference between revisions of "Spring 2022 National ACS Abstract"
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| − | + | '''Synthesis and characterization of Acetaminophen oxidation products''' | |
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Matthew W. Simonson and Bradley E. Sturgeon | Matthew W. Simonson and Bradley E. Sturgeon | ||
| − | Monmouth College, Department of Chemistry | + | ''Monmouth College, Department of Chemistry'' |
Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. Upon overdose, APAP can lead to toxicity in the liver, which accounts for a striking proportion of acute liver failures in the United States annually. Considering the potential for APAP induced hepatotoxicity, our research group has developed a synthesis method for APAP oxidation products in order to further study the metabolites that may form in the liver. Synthesis methods use both enzymatic and electrochemical means. Analysis by HPLC indicates the oxidation of APAP results in the same product outcome, yet electrochemical oxidation yields a more controlled product selection. Further characterization of these APAP oxidation products were carried out using electron spin resonance (ESR), quadruple time-of-flight mass spectrometry (qTOF-MS), and cyclic voltammetry (CV). Our findings purport that APAP prefers to oxidize through a mechanism of radical polymerization, which lends insight into the oxidation cascade that occurs as the liver oxidizes APAP during times of overdose. | Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. Upon overdose, APAP can lead to toxicity in the liver, which accounts for a striking proportion of acute liver failures in the United States annually. Considering the potential for APAP induced hepatotoxicity, our research group has developed a synthesis method for APAP oxidation products in order to further study the metabolites that may form in the liver. Synthesis methods use both enzymatic and electrochemical means. Analysis by HPLC indicates the oxidation of APAP results in the same product outcome, yet electrochemical oxidation yields a more controlled product selection. Further characterization of these APAP oxidation products were carried out using electron spin resonance (ESR), quadruple time-of-flight mass spectrometry (qTOF-MS), and cyclic voltammetry (CV). Our findings purport that APAP prefers to oxidize through a mechanism of radical polymerization, which lends insight into the oxidation cascade that occurs as the liver oxidizes APAP during times of overdose. | ||
Latest revision as of 16:12, 11 October 2021
Synthesis and characterization of Acetaminophen oxidation products
Matthew W. Simonson and Bradley E. Sturgeon
Monmouth College, Department of Chemistry
Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. Upon overdose, APAP can lead to toxicity in the liver, which accounts for a striking proportion of acute liver failures in the United States annually. Considering the potential for APAP induced hepatotoxicity, our research group has developed a synthesis method for APAP oxidation products in order to further study the metabolites that may form in the liver. Synthesis methods use both enzymatic and electrochemical means. Analysis by HPLC indicates the oxidation of APAP results in the same product outcome, yet electrochemical oxidation yields a more controlled product selection. Further characterization of these APAP oxidation products were carried out using electron spin resonance (ESR), quadruple time-of-flight mass spectrometry (qTOF-MS), and cyclic voltammetry (CV). Our findings purport that APAP prefers to oxidize through a mechanism of radical polymerization, which lends insight into the oxidation cascade that occurs as the liver oxidizes APAP during times of overdose.