Difference between revisions of "Ian C Salveson"
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| + | <!-- Greetings...this text does not show up on the page since it is "hidden" with the surrounding tags --> | ||
| + | <!-- This is the suggested format for current students to organize their information; this is NOT a requirement --> | ||
| + | <!-- To add this structure to your personal wiki page, copy and paste the code below and then remove the "hidden" tags --> | ||
| + | <!-- ...then of course...add your information. Use Mr. Bitchly's text for coding examples...pls add examples to this profile --> | ||
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| + | <!-- ==Personal Information== --> | ||
| + | <!-- ==Undergraduate Research Activities== --> | ||
| + | <!-- ==Presentations== --> | ||
| + | <!-- ==Interests== --> | ||
| + | <!-- ==Career Goals== --> | ||
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| + | You have reached the personal page of Styles Bitchly. | ||
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| + | ==Personal Information== | ||
| + | Junior Chemistry and Classics Major | ||
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| + | Hometown: St. Charles, IL | ||
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| + | ==Undergraduate Research Activities== | ||
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| + | Summer 2015: Kieft Summer Research with Brad Sturgeon (Acetaminophen Oxidation) | ||
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| + | Spring 2016: Chem 430 with B. Sturgeon | ||
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| + | ==Presentations== | ||
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| + | June 2014: '''Kieft Summer Research Presentations''' | ||
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| + | Title: A Simulated Study of Acetaminophen Induced Liver Injury''' | ||
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| + | March 2016: '''251th National ACS Meeting''' San Diego, CA | ||
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| + | Poster Title: ''Enzymatic Oxidation of Acetaminophen'' | ||
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| + | ==Interests== | ||
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| + | Water Polo | ||
| + | Cooking | ||
| + | Magic: The Gathering | ||
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| + | ==Career Plans== | ||
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| + | College Chemistry Professor | ||
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==Projects== | ==Projects== | ||
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Flash Chromatography(2/15/2016) | Flash Chromatography(2/15/2016) | ||
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Revision as of 18:06, 29 February 2016
You have reached the personal page of Styles Bitchly.
Personal Information
Junior Chemistry and Classics Major
Hometown: St. Charles, IL
Undergraduate Research Activities
Summer 2015: Kieft Summer Research with Brad Sturgeon (Acetaminophen Oxidation)
Spring 2016: Chem 430 with B. Sturgeon
Presentations
June 2014: Kieft Summer Research Presentations
Title: A Simulated Study of Acetaminophen Induced Liver Injury
March 2016: 251th National ACS Meeting San Diego, CA
Poster Title: Enzymatic Oxidation of Acetaminophen
Interests
Water Polo Cooking Magic: The Gathering
Career Plans
College Chemistry Professor
Projects
The Mechanism of Acetaminophen Metabolism
Acetaminophen, also known as paracetamol, is a commonly used over-the-counter pain reliever. It is also present in mixtures of prescribed pain medication. Taken in accordance with dosage suggestions, acetaminophen is processed normally by the body and does not cause any adverse side effects; however, taken in excess, acetaminophen can quickly lead to liver failure and death. Acetaminophen alone is responsible for 50% of transplants due to drug related liver injury. Correct identification of the mechanism of acetaminophen induced liver damage is the first step in treating and preventing acetaminophen related liver failure. The currently accepted mechanism for liver injury due to acetaminophen involves the creation of a highly reactive oxidation product NAPQI. However, research has identified the formation of a radical during the enzymatic oxidation of acetaminophen. This has led to a new hypothesis where radicals are continuously forming and combining into polymeric material that would cause a buildup of insoluble material within the liver, preventing blood flow and leading to necrosis. This research will revolve around investigating this new hypothesis by analyzing the products of controlled enzymatic oxidations of acetaminophen using HPLC alongside with NMR and Mass Spectroscopy for the characterization of these products.
Experiments
Flash Chromatography(2/15/2016)