Difference between revisions of "Kathryn Saulcy Chem430 F16"
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==Proposed Research Project== | ==Proposed Research Project== | ||
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Insulin: Its Structure, Function, and Interaction in Model Cell Membranes | Insulin: Its Structure, Function, and Interaction in Model Cell Membranes | ||
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===Proposal=== | ===Proposal=== | ||
| − | This semester, I am continuing the research | + | This semester, I am continuing the research from the Doc Kieft Summer Research Program. My work is based on investigating the effects of insulin, both human and bovine, on various lipids that are common components of biological membranes. I am also working to determine the structure of insulin while altering specific variables: concentration, temperature, and the presence of various metal cations (zinc, copper, etc.). I am using a model membrane system knowing as a Langmuir monolayer to determine the interactions of these substances as though they were in living systems. I will also be using the Atomic Force Microscope to image the various conformations that the insulin molecule may take upon exposure to the metals and other variables previously mentioned. |
===Instruments to be used=== | ===Instruments to be used=== | ||
| − | Langmuir Monolayer Trough | + | :Langmuir Monolayer Trough |
| − | Atomic Force Microscope | + | :Atomic Force Microscope |
===References=== | ===References=== | ||
Latest revision as of 21:51, 28 August 2016
Biochemistry Research 430
- Fall 2016
- Kate Saulcy
- Sophomore Biochemistry Major
Research Times
Wednesday 3-6pm (Trough Lab)
Proposed Research Project
Project Title
Insulin: Its Structure, Function, and Interaction in Model Cell Membranes
General Information
- Advisor: Audra Sostarecz
- Other Research Collaborators: Debbie Crans, Colorado State University
Proposal
This semester, I am continuing the research from the Doc Kieft Summer Research Program. My work is based on investigating the effects of insulin, both human and bovine, on various lipids that are common components of biological membranes. I am also working to determine the structure of insulin while altering specific variables: concentration, temperature, and the presence of various metal cations (zinc, copper, etc.). I am using a model membrane system knowing as a Langmuir monolayer to determine the interactions of these substances as though they were in living systems. I will also be using the Atomic Force Microscope to image the various conformations that the insulin molecule may take upon exposure to the metals and other variables previously mentioned.
Instruments to be used
- Langmuir Monolayer Trough
- Atomic Force Microscope
References
Aggregation of Insulin at the Interface (http://pubs.acs.org/doi/pdf/10.1021/jp4101202?src=recsys)
Surface Chemistry and Spectroscopy of Human Insulin Langmuir Monolayer(http://pubs.acs.org/doi/full/10.1021/jp3046643)
Study of the Aggregation of Human Insulin Langmuir Monolayer(http://pubs.acs.org/doi/pdfplus/10.1021/la204201w?src=recsys)
Research pledge
I, Kate Saulcy, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.