Spring 2022 National ACS Abstract - Revision history

Matt1014 at 16:12, 11 October 2021

2021-10-11T16:12:10Z

Matt1014 at 16:11, 11 October 2021

2021-10-11T16:11:54Z

Matt1014: /* Synthesis and Characterization of Acetaminophen Oxidation Products */

2021-10-11T16:02:47Z

Synthesis and Characterization of Acetaminophen Oxidation Products

Matt1014: /* Synthesis and Characterization of Acetaminophen Oxidation Products */

2021-10-11T16:00:01Z

Synthesis and Characterization of Acetaminophen Oxidation Products

Bes: /* Synthesis and Characterization of Acetaminophen Oxidation Products */

2021-10-11T15:58:19Z

Synthesis and Characterization of Acetaminophen Oxidation Products

Bes: /* Synthesis and Characterization of Acetaminophen Oxidation Products */

2021-10-11T15:58:02Z

Synthesis and Characterization of Acetaminophen Oxidation Products

Bes at 15:57, 11 October 2021

2021-10-11T15:57:39Z

Bes at 15:57, 11 October 2021

2021-10-11T15:57:06Z

Matt1014: /* Synthesis and Characterization of Acetaminophen Oxidation Products */

2021-10-11T15:55:28Z

Synthesis and Characterization of Acetaminophen Oxidation Products

Matt1014: /* Synthesis and Characterization of Acetaminophen Oxidation Products */

2021-10-11T15:54:30Z

Synthesis and Characterization of Acetaminophen Oxidation Products

@@ Line 1: / Line 1: @@
 '''Synthesis and characterization of Acetaminophen oxidation products'''
-''Matthew W. Simonson and Bradley E. Sturgeon''
+Matthew W. Simonson and Bradley E. Sturgeon
 ''Monmouth College, Department of Chemistry''
 Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. Upon overdose, APAP can lead to toxicity in the liver, which accounts for a striking proportion of acute liver failures in the United States annually. Considering the potential for APAP induced hepatotoxicity, our research group has developed a synthesis method for APAP oxidation products in order to further study the metabolites that may form in the liver. Synthesis methods use both enzymatic and electrochemical means. Analysis by HPLC indicates the oxidation of APAP results in the same product outcome, yet electrochemical oxidation yields a more controlled product selection. Further characterization of these APAP oxidation products were carried out using electron spin resonance (ESR), quadruple time-of-flight mass spectrometry (qTOF-MS), and cyclic voltammetry (CV). Our findings purport that APAP prefers to oxidize through a mechanism of radical polymerization, which lends insight into the oxidation cascade that occurs as the liver oxidizes APAP during times of overdose.

@@ Line 1: / Line 1: @@
 '''Synthesis and characterization of Acetaminophen oxidation products'''
-Monmouth College, Department of Chemistry
+''Matthew W. Simonson and Bradley E. Sturgeon''
 Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. Upon overdose, APAP can lead to toxicity in the liver, which accounts for a striking proportion of acute liver failures in the United States annually. Considering the potential for APAP induced hepatotoxicity, our research group has developed a synthesis method for APAP oxidation products in order to further study the metabolites that may form in the liver. Synthesis methods use both enzymatic and electrochemical means. Analysis by HPLC indicates the oxidation of APAP results in the same product outcome, yet electrochemical oxidation yields a more controlled product selection. Further characterization of these APAP oxidation products were carried out using electron spin resonance (ESR), quadruple time-of-flight mass spectrometry (qTOF-MS), and cyclic voltammetry (CV). Our findings purport that APAP prefers to oxidize through a mechanism of radical polymerization, which lends insight into the oxidation cascade that occurs as the liver oxidizes APAP during times of overdose.

← Older revision		Revision as of 16:02, 11 October 2021
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−	==Synthesis and ~~Characterization~~ of Acetaminophen ~~Oxidation Products==~~	+	'''Synthesis and characterization of Acetaminophen oxidation products'''
	Matthew W. Simonson and Bradley E. Sturgeon		Matthew W. Simonson and Bradley E. Sturgeon

← Older revision		Revision as of 16:00, 11 October 2021
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	Monmouth College, Department of Chemistry		Monmouth College, Department of Chemistry

−	Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. Upon overdose, APAP can lead to toxicity in the liver, which accounts for a striking proportion of acute liver failures in the United States annually. Considering the potential for APAP induced hepatotoxicity, our research group has developed a synthesis method for APAP oxidation products in order to further study the metabolites that may form in the liver. Synthesis methods use both enzymatic and electrochemical means. Analysis by HPLC indicates the oxidation of APAP results in the same product outcome, yet electrochemical oxidation yields a more controlled product selection. Further characterization of these APAP oxidation products were carried out using electron spin resonance (ESR), quadruple time-of-flight mass spectrometry (qTOF-MS), and cyclic voltammetry (CV). Our findings purport that APAP prefers to oxidize through a mechanism of radical polymerization, which lends insight into the oxidation cascade that occurs as the liver oxidizes APAP during times of overdose~~. Furthermore, the synthesis of four APAP oxidation products in high yield has important implications in understanding their potential biological activity~~.	+	Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. Upon overdose, APAP can lead to toxicity in the liver, which accounts for a striking proportion of acute liver failures in the United States annually. Considering the potential for APAP induced hepatotoxicity, our research group has developed a synthesis method for APAP oxidation products in order to further study the metabolites that may form in the liver. Synthesis methods use both enzymatic and electrochemical means. Analysis by HPLC indicates the oxidation of APAP results in the same product outcome, yet electrochemical oxidation yields a more controlled product selection. Further characterization of these APAP oxidation products were carried out using electron spin resonance (ESR), quadruple time-of-flight mass spectrometry (qTOF-MS), and cyclic voltammetry (CV). Our findings purport that APAP prefers to oxidize through a mechanism of radical polymerization, which lends insight into the oxidation cascade that occurs as the liver oxidizes APAP during times of overdose.

← Older revision		Revision as of 15:58, 11 October 2021
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	Monmouth College, Department of Chemistry		Monmouth College, Department of Chemistry

−	Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. Upon overdose, APAP can lead to toxicity in the liver, which accounts for a striking proportion of acute liver failures in the United States annually. Considering the potential for APAP induced hepatotoxicity, our research group has developed a synthesis method for APAP oxidation products in order to further study the metabolites that may form in the liver. Synthesis methods use both enzymatic and electrochemical means. Analysis by ~~high performance~~ HPLC indicates the oxidation of APAP results in the same product outcome, yet electrochemical oxidation yields a more controlled product selection. Further characterization of these APAP oxidation products were carried out using electron spin resonance (ESR), quadruple time-of-flight mass spectrometry (qTOF-MS), and cyclic voltammetry (CV). Our findings purport that APAP prefers to oxidize through a mechanism of radical polymerization, which lends insight into the oxidation cascade that occurs as the liver oxidizes APAP during times of overdose. Furthermore, the synthesis of four APAP oxidation products in high yield has important implications in understanding their potential biological activity.	+	Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. Upon overdose, APAP can lead to toxicity in the liver, which accounts for a striking proportion of acute liver failures in the United States annually. Considering the potential for APAP induced hepatotoxicity, our research group has developed a synthesis method for APAP oxidation products in order to further study the metabolites that may form in the liver. Synthesis methods use both enzymatic and electrochemical means. Analysis by HPLC indicates the oxidation of APAP results in the same product outcome, yet electrochemical oxidation yields a more controlled product selection. Further characterization of these APAP oxidation products were carried out using electron spin resonance (ESR), quadruple time-of-flight mass spectrometry (qTOF-MS), and cyclic voltammetry (CV). Our findings purport that APAP prefers to oxidize through a mechanism of radical polymerization, which lends insight into the oxidation cascade that occurs as the liver oxidizes APAP during times of overdose. Furthermore, the synthesis of four APAP oxidation products in high yield has important implications in understanding their potential biological activity.

← Older revision		Revision as of 15:57, 11 October 2021
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	Monmouth College, Department of Chemistry		Monmouth College, Department of Chemistry

−	Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. Upon overdose, APAP can lead to toxicity in the liver, which accounts for a striking proportion of acute liver failures in the United States annually. Considering the potential for APAP induced hepatotoxicity, our research group has developed a synthesis method for APAP oxidation products in order to further study the metabolites that may form in the liver. Synthesis methods use both enzymatic and electrochemical means. Analysis of both reactions by high performance ~~liquid chromatography (~~HPLC) indicates the oxidation of APAP results in the same product outcome, yet electrochemical oxidation yields a more controlled product selection. Further characterization of these APAP oxidation products were carried out using electron spin resonance (ESR), quadruple time-of-flight mass spectrometry (qTOF-MS), and cyclic voltammetry (CV). Our findings purport that APAP prefers to oxidize through a mechanism of radical polymerization, which lends insight into the oxidation cascade that occurs as the liver oxidizes APAP during times of overdose. Furthermore, the synthesis of four APAP oxidation products in high yield has important implications in understanding their potential biological activity.	+	Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. Upon overdose, APAP can lead to toxicity in the liver, which accounts for a striking proportion of acute liver failures in the United States annually. Considering the potential for APAP induced hepatotoxicity, our research group has developed a synthesis method for APAP oxidation products in order to further study the metabolites that may form in the liver. Synthesis methods use both enzymatic and electrochemical means. Analysis of both reactions by high performance HPLC indicates the oxidation of APAP results in the same product outcome, yet electrochemical oxidation yields a more controlled product selection. Further characterization of these APAP oxidation products were carried out using electron spin resonance (ESR), quadruple time-of-flight mass spectrometry (qTOF-MS), and cyclic voltammetry (CV). Our findings purport that APAP prefers to oxidize through a mechanism of radical polymerization, which lends insight into the oxidation cascade that occurs as the liver oxidizes APAP during times of overdose. Furthermore, the synthesis of four APAP oxidation products in high yield has important implications in understanding their potential biological activity.

← Older revision		Revision as of 15:55, 11 October 2021
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	Monmouth College, Department of Chemistry		Monmouth College, Department of Chemistry

−	Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. Upon overdose, APAP can lead to toxicity in the liver, which accounts for a striking proportion of acute liver failures in the United States annually. Considering the potential for APAP induced hepatotoxicity, our research group has developed a synthesis method for APAP oxidation products in order to further study the metabolites that may form in the liver. Synthesis methods ~~were explored~~ using oxidation mechanisms of both enzymatic ~~oxidation~~ and bulk electrolysis. Analysis of both reactions by high performance liquid chromatography (HPLC) indicates the oxidation of APAP results in the same product outcome, yet electrochemical oxidation yields a more controlled product selection. Further characterization of these APAP oxidation products were carried out using electron spin resonance (ESR), quadruple time-of-flight mass spectrometry (qTOF-MS), and cyclic voltammetry (CV). Our findings purport that APAP prefers to oxidize through a mechanism of radical polymerization, which lends insight into the oxidation cascade that occurs as the liver oxidizes APAP during times of overdose. Furthermore, the synthesis of four APAP oxidation products in high yield has important implications in understanding their potential biological activity.	+	Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. Upon overdose, APAP can lead to toxicity in the liver, which accounts for a striking proportion of acute liver failures in the United States annually. Considering the potential for APAP induced hepatotoxicity, our research group has developed a synthesis method for APAP oxidation products in order to further study the metabolites that may form in the liver. Synthesis methods using oxidation mechanisms of both enzymatic and bulk electrolysis. Analysis of both reactions by high performance liquid chromatography (HPLC) indicates the oxidation of APAP results in the same product outcome, yet electrochemical oxidation yields a more controlled product selection. Further characterization of these APAP oxidation products were carried out using electron spin resonance (ESR), quadruple time-of-flight mass spectrometry (qTOF-MS), and cyclic voltammetry (CV). Our findings purport that APAP prefers to oxidize through a mechanism of radical polymerization, which lends insight into the oxidation cascade that occurs as the liver oxidizes APAP during times of overdose. Furthermore, the synthesis of four APAP oxidation products in high yield has important implications in understanding their potential biological activity.

← Older revision		Revision as of 15:54, 11 October 2021
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	Monmouth College, Department of Chemistry		Monmouth College, Department of Chemistry

−	Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. Upon overdose, APAP can lead to toxicity in the liver, which accounts for a striking proportion of acute liver failures in the United States annually. Considering the potential for APAP induced hepatotoxicity, our research group has developed a synthesis method for APAP oxidation products in order to further study the metabolites that form in the liver ~~during APAP overdose~~. Synthesis methods were explored using oxidation mechanisms of both enzymatic oxidation and bulk electrolysis. Analysis of both reactions by high performance liquid chromatography (HPLC) indicates the oxidation of APAP results in the same product outcome, yet electrochemical oxidation yields a more controlled product selection. Further characterization of these APAP oxidation products were carried out using electron spin resonance (ESR), quadruple time-of-flight mass spectrometry (qTOF-MS), and cyclic voltammetry (CV). Our findings purport that APAP prefers to oxidize through a mechanism of radical polymerization, which lends insight into the oxidation cascade that occurs as the liver oxidizes APAP during times of overdose. Furthermore, the synthesis of four APAP oxidation products in high yield has important implications in understanding their potential biological activity.	+	Acetaminophen (APAP) is a common analgesic and an active ingredient in many painkillers such as Tylenol and Percocet. Upon overdose, APAP can lead to toxicity in the liver, which accounts for a striking proportion of acute liver failures in the United States annually. Considering the potential for APAP induced hepatotoxicity, our research group has developed a synthesis method for APAP oxidation products in order to further study the metabolites that may form in the liver. Synthesis methods were explored using oxidation mechanisms of both enzymatic oxidation and bulk electrolysis. Analysis of both reactions by high performance liquid chromatography (HPLC) indicates the oxidation of APAP results in the same product outcome, yet electrochemical oxidation yields a more controlled product selection. Further characterization of these APAP oxidation products were carried out using electron spin resonance (ESR), quadruple time-of-flight mass spectrometry (qTOF-MS), and cyclic voltammetry (CV). Our findings purport that APAP prefers to oxidize through a mechanism of radical polymerization, which lends insight into the oxidation cascade that occurs as the liver oxidizes APAP during times of overdose. Furthermore, the synthesis of four APAP oxidation products in high yield has important implications in understanding their potential biological activity.