Kathryn Saulcy Chem430 F16 - Revision history

Kate saulcy: /* Proposal */

2016-08-28T21:51:20Z

Proposal

Kate saulcy: /* Proposed Research Project */

2016-08-28T21:50:24Z

Proposed Research Project

Kate saulcy at 21:47, 28 August 2016

2016-08-28T21:47:14Z

Kate saulcy: Created page with "Biochemistry Research 430 :Fall 2016 :Kate Saulcy :Sophomore Biochemistry Major ==Research Times== Wednesday 3-6pm (Trough Lab) ==Proposed Research Project== Studying the st..."

2016-08-28T21:45:45Z

Created page with "Biochemistry Research 430 :Fall 2016 :Kate Saulcy :Sophomore Biochemistry Major ==Research Times== Wednesday 3-6pm (Trough Lab) ==Proposed Research Project== Studying the st..."

New page

Biochemistry Research 430
:Fall 2016
:Kate Saulcy
:Sophomore Biochemistry Major

==Research Times==
Wednesday 3-6pm (Trough Lab)

==Proposed Research Project==
Studying the structure and determining the function of insulin in the presence of various lipids.

===Enter Project Title here===
Insulin: Its Structure, Function, and Interaction in Model Cell Membranes

===General Information===
:Advisor: Audra Sostarecz
:Other Research Collaborators: Debbie Crans, Colorado State University

===Proposal===
This semester, I am continuing the research that I did during the Doc Kieft Summer Research Program over the summer. My work is based on investigating the effects of insulin, both human and bovine, on various lipids that are common components of biological membranes. I am also working to determine the structure of insulin while altering specific variables: concentration, temperature, and the presence of various metal cations (zinc, copper, etc.). I am using a model membrane system knowing as a Langmuir monolayer to determine the interactions of these substances as though they were in living systems. I will also be using the Atomic Force Microscope to image the various conformations that the insulin molecule may take upon exposure to the metals and other variables previously mentioned.

===Instruments to be used===
Langmuir Monolayer Trough
Atomic Force Microscope

===References===
Aggregation of Insulin at the Interface (http://pubs.acs.org/doi/pdf/10.1021/jp4101202?src=recsys)

Surface Chemistry and Spectroscopy of Human Insulin Langmuir Monolayer(http://pubs.acs.org/doi/full/10.1021/jp3046643)

Study of the Aggregation of Human Insulin Langmuir Monolayer(http://pubs.acs.org/doi/pdfplus/10.1021/la204201w?src=recsys)

===Research pledge===
I, Kate Saulcy, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.

@@ Line 18: / Line 18: @@
 ===Proposal===
-This semester, I am continuing the research that I did during the Doc Kieft Summer Research Program over the summer. My work is based on investigating the effects of insulin, both human and bovine, on various lipids that are common components of biological membranes.  I am also working to determine the structure of insulin while altering specific variables: concentration, temperature, and the presence of various metal cations (zinc, copper, etc.). I am using a model membrane system knowing as a Langmuir monolayer to determine the interactions of these substances as though they were in living systems. I will also be using the Atomic Force Microscope to image the various conformations that the insulin molecule may take upon exposure to the metals and other variables previously mentioned.
+This semester, I am continuing the research from the Doc Kieft Summer Research Program. My work is based on investigating the effects of insulin, both human and bovine, on various lipids that are common components of biological membranes.  I am also working to determine the structure of insulin while altering specific variables: concentration, temperature, and the presence of various metal cations (zinc, copper, etc.). I am using a model membrane system knowing as a Langmuir monolayer to determine the interactions of these substances as though they were in living systems. I will also be using the Atomic Force Microscope to image the various conformations that the insulin molecule may take upon exposure to the metals and other variables previously mentioned.
 ===Instruments to be used===

@@ Line 8: / Line 8: @@
 ==Proposed Research Project==
-Studying the structure and determining the function of insulin in the presence of various lipids.
 ===Project Title===

@@ Line 10: / Line 10: @@
 Studying the structure and determining the function of insulin in the presence of various lipids.
-===Enter Project Title here===
+===Project Title===
 Insulin: Its Structure, Function, and Interaction in Model Cell Membranes
@@ Line 21: / Line 21: @@
 ===Instruments to be used===
-Langmuir Monolayer Trough
+:Langmuir Monolayer Trough
-Atomic Force Microscope
+:Atomic Force Microscope
 ===References===