Acetaminophen - Revision history

Benstillwell: /* Radical Coupling of Acetaminophen */

2018-04-20T15:38:15Z

Radical Coupling of Acetaminophen

2018-04-20T15:37:10Z

History of Acetaminophen

2018-04-20T15:34:17Z

2018-04-20T15:21:38Z

Metabolism and Hepatoxicity

2018-04-20T15:21:00Z

Metabolism and Hepatoxicity

2018-04-20T15:17:23Z

History of Acetaminophen

2018-04-20T15:16:42Z

History of Acetaminophen

2018-04-20T15:15:42Z

History of Acetaminophen

2018-04-20T15:10:52Z

History of Acetaminophen

2018-04-20T15:10:23Z

@@ Line 74: / Line 74: @@
 EPR spectrum of APAP radical formed by horseradish peroxidase and hydrogen peroxide with 50% pH 5/ 50% dioxane flowed at 1 mL/min (top).  The three spectrum below the top are computer simulations depicting the APAP radical in a melanin-like polymer, APAP radical by itself, and a combination of the two bottom simulations to match the experimental data (from bottom to top).
 |}
 =Sources=

@@ Line 13: / Line 13: @@
 - Acetanilide, the first anilide derivative with analgesic and antipyretic properties discovered by A. Cahn and P. Hepp
-[[File:acetanilide.png|200px|thumb|none|Phenacetin]]
+[[File:acetanilide.png|200px|thumb|none|Acetanilide]]
 - Phenacetin, a similar and seemingly less toxic anilide is found by Joseph Von Merring to have the same properties as acetanilide

@@ Line 74: / Line 74: @@
 EPR spectrum of APAP radical formed by horseradish peroxidase and hydrogen peroxide with 50% pH 5/ 50% dioxane flowed at 1 mL/min (top).  The three spectrum below the top are computer simulations depicting the APAP radical in a melanin-like polymer, APAP radical by itself, and a combination of the two bottom simulations to match the experimental data (from bottom to top).
 |}
 =Sources=

@@ Line 44: / Line 44: @@
 General metabolism of acetaminophen which includes the nonreactive metabolites through glucoronidation and sulfation as well as the toxic pathway through the enzymatic oxidation.
 |}
 =Acetaminophen Free Radical Detection via EPR=

@@ Line 44: / Line 44: @@
 General metabolism of acetaminophen which includes the nonreactive metabolites through glucoronidation and sulfation as well as the toxic pathway through the enzymatic oxidation.
 |}
 =Acetaminophen Free Radical Detection via EPR=

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 - Acetaminophen synthesized by Harmon Northrop Morse however it would take decades for the potential of the drug to be understood.
-- Acetanilide, the first anilide derivative with analgesic and antipyretic properties discovered by A. Cahn and P. Hepp (Include Structure)
+- Acetanilide, the first anilide derivative with analgesic and antipyretic properties discovered by A. Cahn and P. Hepp
-- Phenacetin, a similar and seemingly less toxic anilide is found by Joseph Von Merring to have the same properties as acetanilide (Include Structure)
+[[File:acetanilide.png|200px|thumb|none|Acetanilide]]
 - The white, odorless crystal compound of acetaminophen is discovered at the University of Strasburg by Adolf Kussmaul and his team. The drug is used briefly as an analgesic but was discarded in favor of phenacetin, due to fears of methemoglobinemia by acetaminophen
@@ Line 24: / Line 28: @@
 - Acetaminophen is available OTC and has since become a household drug.
 =Medical Uses=

@@ Line 26: / Line 26: @@
-[[File:acetanilide.png|200px|thumb|none|APAP]]
+[[File:acetanilide.png|200px|thumb|none|Acetanilide]]
-[[File:phenacetin.png|200px|thumb|none|APAP]]
+[[File:phenacetin.png|200px|thumb|none|Phenacetin]]
 =Medical Uses=

← Older revision		Revision as of 15:10, 20 April 2018
Line 24:		Line 24:

	1959- Acetaminophen is available OTC and has since become a household drug.		1959- Acetaminophen is available OTC and has since become a household drug.
		+
		+
		+	[[File:acetanilide.png\|200px\|thumb\|none\|APAP]]
		+
		+	[[File:phenacetin.png\|200px\|thumb\|none\|APAP]]

	=Medical Uses=		=Medical Uses=