MC Chem Wiki - User contributions [en]

Research Report Template

2017-12-02T02:41:16Z

Samer Al jundi: /* Enter Paper Title Here */

==Cyclic Voltammetry==

==Introduction==

State the motivation for the project in terms of current literature. This section can be largely copied from an earlier report(s), if they exist, but it is expected that this section is edited to include newly found background information. Note: if the author of previous reports is included as a contributor to the project, you may cut and paste text; this is not plagiarism.

==Materials and Methods==

This section describes experiments done during the period covered by the report. Usually, this work will be similar or identical to that described in the prior report, if they exists. Any new experiments will be written up and added to the experimental section.

==Results==

This section documents the results of the experiments done during the period covered by the report. Tabulation of data is encouraged; representative spectra presented.

==Discussion==

In this section, you will discuss the results of their work in context of the literature and the results of earlier reports. Questions that have been raised in earlier reports may be addressed here.

==References==

Self explanatory...

Thermal Car Images

2017-09-07T20:05:25Z

Samer Al jundi: Created page with " 400px 400px before and after driving the car."

[[File:before.jpg|400px]]

[[File:after.jpg|400px]]

before and after driving the car.

File:After.jpg

2017-09-07T20:04:38Z

Samer Al jundi: Samer Al jundi uploaded a new version of File:After.jpg

File uploaded with MsUpload

File:Before.jpg

2017-09-07T20:04:23Z

Samer Al jundi: Samer Al jundi uploaded a new version of File:Before.jpg

File uploaded with MsUpload

Samer Aljundi

2017-09-07T05:50:42Z

Samer Al jundi:

before driving

[[File:before.jpg|400px]]

after driving

[[File:after.jpg|400px]]

Noticed that after driving the car for 15 minutes, the engine's temperature increased.

Samer Aljundi

2017-09-07T05:46:59Z

Samer Al jundi:

before driving
[[File:before.jpg|400px]]

after driving
[[File:after.jpg|400px]]

Samer Aljundi

2017-09-07T05:45:49Z

Samer Al jundi: Created page with "400px400px"

[[File:before.jpg|400px]][[File:after.jpg|400px]]

File:After.jpg

2017-09-07T05:45:42Z

Samer Al jundi: File uploaded with MsUpload

File uploaded with MsUpload

File:Before.jpg

2017-09-07T05:45:16Z

Samer Al jundi: File uploaded with MsUpload

File uploaded with MsUpload

Absolute zero reflection

2017-08-24T22:16:32Z

Samer Al jundi: Created page with "The movie “Absolute Zero” directed by David H. Khoch was beneficial to watch, engaging and enjoyable. The storytelling technique that was used made it easier to watch and..."

The movie “Absolute Zero” directed by David H. Khoch was beneficial to watch, engaging and enjoyable. The storytelling technique that was used made it easier to watch and kept the audience engaged throughout the movie. It was fascinating to learn how discovering how cold worked very long time ago was mostly based on superstitions and evilness. Also, it was exciting to know that it all started in the movie with an alchemist/magician that wanted to show people that he can change summer into winter in minutes.

The movie was talking about the history of cold and how scientists like Celsius, Fahrenheit, Faraday and Thompson helped with the improvement of the theories that they all made throughout the centuries and led us to our knowledge nowadays about cold. In this class we will be studying thermodynamics more thoroughly therefore it was beneficial to have a background about the different theories about different temperature and pressured molecules and how they came to the understanding of energy and how temperature can be used in movement and the other way around.

it was important for us to look back of how the world we live in these days started after the industrial revelation and after James Joule revolutionized the theories about energy taking more than a form of temperature, that heat or cold can be granted from movement and having movement from the use of heat or cold knowing that it is conserved. Moreover, it was very educational of how today’s most purchased food or air conditioners have the names of the people like Bird’s Eye and Willis Carrier whom helped in changing the history of cooling industry and changing our world today. So this movie was interesting and beneficial to watch and create a good informational background before we start learning thermodynamics.

Pinacyanol chloride

2017-02-09T23:21:23Z

Samer Al jundi:

Pinacyanol chloride

2017-02-09T23:18:43Z

Samer Al jundi:

Pinacyanol chloride

2017-02-09T23:17:03Z

Samer Al jundi:

By Samer Aljundi
[[File:Pinacyanol chloride.png|400px|thumb|left|Pinacyanol chloride]]

Pinacyanol chloride

2017-02-09T23:16:40Z

Samer Al jundi:

By Samer Aljundi
[[File:Pinacyanol chloride.png|200px|thumb|left|Pinacyanol chloride]]

Pinacyanol chloride

2017-02-09T23:14:43Z

Samer Al jundi:

By Samer Aljundi
[[Media:Pinacyanol chloride.png|Pinacyanol chloride]]

File:Pinacyanol chloride.png

2017-02-09T23:11:27Z

Samer Al jundi:

File:Graph000.jpg

2017-02-09T23:07:28Z

Samer Al jundi:

Pinacyanol chloride

2017-02-09T22:49:24Z

Samer Al jundi: Created page with "By Samer Aljundi"

By Samer Aljundi

Samer Aljundi Chem430 F16

2017-02-03T21:51:04Z

Samer Al jundi: /* Research Times */

Chemistry Research 430
:Fall 2016
:Samer Aljundi
:Senior Chemistry Major

==Research Times==
Mon/Tue/Fri 2-5 pm
Science Seminar: April 28th

==Proposed Research Project==
===Research===

===General Information===
:Advisor: Sturgeon, Bradley E

===Proposal===

Acetaminophen will be tested to determine the concentration in a sample of elixir using compact voltammetry cell and applying the cyclic voltammetry which is an electrochemical method.

===Instruments to be used===

WaveNow ™ USB potentiostat with AfterMath ™ software.

===Research pledge===
I, Samer Aljundi, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.

Samer Aljundi Chem430 F16

2017-02-03T21:50:56Z

Samer Al jundi: /* General Information */

Chemistry Research 430
:Fall 2016
:Samer Aljundi
:Senior Chemistry Major

==Research Times==
Mon/Tue/Fri 2-5 pm

==Proposed Research Project==
===Research===

===General Information===
:Advisor: Sturgeon, Bradley E

===Proposal===

Acetaminophen will be tested to determine the concentration in a sample of elixir using compact voltammetry cell and applying the cyclic voltammetry which is an electrochemical method.

===Instruments to be used===

WaveNow ™ USB potentiostat with AfterMath ™ software.

===Research pledge===
I, Samer Aljundi, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.

Samer Aljundi Chem430 F16

2017-02-03T21:50:26Z

Samer Al jundi: /* General Information */

Chemistry Research 430
:Fall 2016
:Samer Aljundi
:Senior Chemistry Major

==Research Times==
Mon/Tue/Fri 2-5 pm

==Proposed Research Project==
===Research===

===General Information===
:Advisor: Sturgeon, Bradley E
Science Seminar: April 28th

===Proposal===

Acetaminophen will be tested to determine the concentration in a sample of elixir using compact voltammetry cell and applying the cyclic voltammetry which is an electrochemical method.

===Instruments to be used===

WaveNow ™ USB potentiostat with AfterMath ™ software.

===Research pledge===
I, Samer Aljundi, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.

Current Spring 2017

2017-02-03T21:48:03Z

Samer Al jundi: /* Electrochemical Measurements */

===Electrochemical Measurements===
[[Mirna_Alhanash_Chem430_S17|Mirna Alhanash]]

[[Samer_Aljundi_Chem430_F16|Samer Aljundi]]

Weekly meeting time:

===EPR===
[[Carley_Folluo_Chem430_S17|Carley Folluo]]

Weekly Meeting time: 1 pm Tues

===Peroxidase===
[[Ian_Salveson_Chem430_S17|Ian Salveson]]

[[Ricketts-Hagan_Jeffrey_Chem430_S17|Jeffrey Ricketts-Hagan]]

Weekly Meeting time:

===Chlorogenic Acid===
[[Alan_Kuhlemier_Chem430_S17|Alan Kuhlemier]]

Weekly Meeting time: Weds 3 pm

===Turmeric===
[[Ayala_Nadia_BIOC430_S17|Nadia Y. Ayala]]

[[Stephanie_Saey_BIOC430_F17|Stephanie Saey]]

Weekly Meeting time: Thurs 11 am

===Essential Oils===
[[Benjamin_Stillwell_BIOC430_S17|Benjamin Stillwell]] weekly meeting time: Mon 11 am

[[Hounsve_Selene_BIOC430_S17|Selene Hounsve]]

[[Sarah_Lang_BIOC430_S17|Sarah Lang]] weekly meeting time: Weds 2 pm

===Sugars===
[[Ryne_Krejci_BIOC430_S17|Ryne Krejci]]

Weekly Meeting time:

Current Spring 2017

2017-02-03T21:46:56Z

Samer Al jundi: /* Electrochemical Measurements */

===Electrochemical Measurements===
[[Mirna_Alhanash_Chem430_S17|Mirna Alhanash]]

[[Samer_Aljundi_Chem430_s16|Samer Aljundi]]

Weekly meeting time:

===EPR===
[[Carley_Folluo_Chem430_S17|Carley Folluo]]

Weekly Meeting time: 1 pm Tues

===Peroxidase===
[[Ian_Salveson_Chem430_S17|Ian Salveson]]

[[Ricketts-Hagan_Jeffrey_Chem430_S17|Jeffrey Ricketts-Hagan]]

Weekly Meeting time:

===Chlorogenic Acid===
[[Alan_Kuhlemier_Chem430_S17|Alan Kuhlemier]]

Weekly Meeting time: Weds 3 pm

===Turmeric===
[[Ayala_Nadia_BIOC430_S17|Nadia Y. Ayala]]

[[Stephanie_Saey_BIOC430_F17|Stephanie Saey]]

Weekly Meeting time: Thurs 11 am

===Essential Oils===
[[Benjamin_Stillwell_BIOC430_S17|Benjamin Stillwell]] weekly meeting time: Mon 11 am

[[Hounsve_Selene_BIOC430_S17|Selene Hounsve]]

[[Sarah_Lang_BIOC430_S17|Sarah Lang]] weekly meeting time: Weds 2 pm

===Sugars===
[[Ryne_Krejci_BIOC430_S17|Ryne Krejci]]

Weekly Meeting time:

Samer Aljundi Chem430 F16

2017-02-03T17:54:56Z

Samer Al jundi: /* Instruments to be used */

Samer Aljundi Chem430 F16

2017-02-03T17:54:21Z

Samer Al jundi: /* Proposal */

Chemistry Research 430
:Fall 2016
:Samer Aljundi
:Senior Chemistry Major

==Research Times==
Mon/Tue/Fri 2-5 pm

==Proposed Research Project==
===Research===

===General Information===
:Advisor: Sturgeon, Bradley E

===Proposal===

Acetaminophen will be tested to determine the concentration in a sample of elixir using compact voltammetry cell and applying the cyclic voltammetry which is an electrochemical method.

===Instruments to be used===
Still working on it.

===Research pledge===
I, Samer Aljundi, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.

Samer Aljundi Chem430 F16

2017-01-30T07:35:45Z

Samer Al jundi: /* ADME Research */

Chemistry Research 430
:Fall 2016
:Samer Aljundi
:Senior Chemistry Major

==Research Times==
Mon/Tue/Fri 2-5 pm

==Proposed Research Project==
===Research===

===General Information===
:Advisor: Sturgeon, Bradley E

===Proposal===
Still working on it.
===Instruments to be used===
Still working on it.

===Research pledge===
I, Samer Aljundi, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.

Samer Aljundi Chem430 F16

2017-01-30T07:35:15Z

Samer Al jundi: /* Research Times */

Chemistry Research 430
:Fall 2016
:Samer Aljundi
:Senior Chemistry Major

==Research Times==
Mon/Tue/Fri 2-5 pm

==Proposed Research Project==
===ADME Research===

===General Information===
:Advisor: Sturgeon, Bradley E

===Proposal===
Still working on it.
===Instruments to be used===
Still working on it.

===Research pledge===
I, Samer Aljundi, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.

File:Lab light.jpeg

2017-01-26T22:56:41Z

Samer Al jundi:

This data have been worked on Igor. We used red tide USB 650 to get the light intensity and the light wavelength. We used Christmas light at the first, then we submerge the Christmas light in a liquid Nitrogen and get this data.
The black line is the Christmas light with no submerge, the red line is the submerged Christmas light.

File:Lab light.jpeg

2017-01-26T22:53:36Z

Samer Al jundi: This data have been worked on Igor. We used red tide USB 650 to get the light intensity and the light wavelength. We used Christmas light at the first, then we submerge the Christmas light in a liquid Nitrogen and get this data.

Talk:Samer Aljundi Chem430 F16

2016-09-12T04:17:59Z

Samer Al jundi: Created page with "- ADME is an abbreviation in pharmacokinetics and pharmacology for "absorption, distribution, metabolism, and excretion," and describes the disposition of apharmaceutical comp..."

- ADME is an abbreviation in pharmacokinetics and pharmacology for "absorption, distribution, metabolism, and excretion," and describes the disposition of apharmaceutical compound within an organism. The four criteria all influence the drug levels and kinetics of drug exposure to the tissues and hence influence the performance and pharmacological activity of the compound as a drug. (https://en.wikipedia.org/wiki/ADME)

- ADME Studies
- Preclinical ADME studies are designed to investigate the absorption, distribution, metabolism and excretion of novel pharmaceuticals to support lead candidate selection, preclinical testing and clinical development programs. Charles River offers custom-designed ADME studies in multiple species using cold or radiolabeled test materials administered by a variety of routes.
- Our experienced scientists routinely conduct mass balance and tissue distribution studies to determine tissue half-life, clearance rates and potential sites of toxicity after systemic exposure. These studies are all managed using the DEBRA® Windows LIMS System to provide full electronic data collection and evaluation. We can arrange and manage custom radiosynthesis on your behalf and are able to undertake re-purification and radiodilution of radiolabeled test materials if required. (http://www.criver.com/products-services/safety-assessment/toxicology/drug-metabolism-pharmacokinetics/adme)

- Discovering a new drug is a complex but sequential process from discovery to preclinical development, followed with clinical drug development. It has been estimated that ∼ 87% of the phase III failures are accounted for either due to lack of efficacy (66%) or due to safety issues (21%). Majority of these failures are for compounds targeted for novel mechanisms of actions with unmet medical need, in particular, oncology and neurodegenerative disorders. Some of the reasons for these failures can be attributed to lack of appropriate preclinical animal models, biomarkers/surrogate markers, and effective pharmacokinetic (PK)–pharmacodynamic (PD) evaluation during early drug discovery. Translational research that integrates computer-aided drug design (CADD), PK, PD, drug metabolism (DM), and drug transport along with biomarkers and humanized animal models are instrumental in making informed decisions from early drug discovery through clinical development. The ability to correlate drug effect through modeling and simulations starts from early drug discovery and preclinical evaluation, including use of novel biomarkers. Such models validate the PK and PD relationships and provide a basis for their applications and guide the Phase I through Phase III clinical trials more effectively, minimizing the late stage failures. Thus, PK–PD evaluation has become an integral part of drug discovery and provides valuable insights to aid in optimizing the next steps for drug development. This chapter is focused on translational drug discovery research with particular emphasis on selective utilization of CADD; absorption, distribution, metabolism, and excretion; toxicology; PK; and PD evaluations, which identify potential liabilities early so as to minimize late-stage failures during drug development. This chapter also provides a brief overview on means and measures that can be adopted to integrate early drug discovery research along with efficacy and safety biomarkers for meaningful transition to drug development. (http://onlinelibrary.wiley.com/doi/10.1002/9780470921920.edm038/abstract)

- Abstract
- There is an increasing recognition within the pharmaceutical industry of the importance of the ADME studies in drug registration. Consequently, there has been a drive in recent times to conduct the ADME studies as early as possible in the development programme. There are, however, regulatory barriers, particularly in the administration of radiotracers to human volunteers, which place limitations on the timing of the ADME studies. Accelerator mass spectrometry (AMS), a technology new to the pharmaceutical industry, is an ultrasensitive technique for measuring tracers such as 14C. Using AMS, it is possible to lower the radioactive dose administered to humans to a point where many regulatory authorities consider it insignificant. With the removal of the regulatory hurdles, ADME data can be obtained much earlier in the development process. Tracers such as 14C can be administered in minute amounts in the first in man studies (Phase I), or even in a preregulatory study known as microdosing (or human Phase 0). AMS also enables other studies such as absolute bioavailability to be conducted earlier if required. (http://www.tandfonline.com/doi/abs/10.1517/17425255.1.1.23)

- An understanding of the functional roles of proteins, for example, in drug absorption, distribution, metabolism, elimination, toxicity, and efficacy (ADMET/efficacy), is important for drug discovery and development. Equally, detailed information about protein expression is required. Recently, a new protein quantification method, called quantitative targeted absolute proteomics (QTAP), has been developed on the basis of separation and identification of protein digests by liquid chromatography–linked tandem mass spectrometry with multiple reaction monitoring. Target peptides for quantification are selected only from sequence information, so time-consuming procedures such as antibody preparation and protein purification are unnecessary. In this review, we introduce the technical features of QTAP and summarize its advantages with reference to recently reported results. These include the evaluation of species differences of blood–brain barrier protein levels among human, monkey, and mouse. The high selectivity of QTAP and its ability to quantify multiple proteins simultaneously make it possible to determine the absolute expression levels of many proteins in tissues and cells in both physiological and disease states. Knowledge of absolute expression amounts, together with data on intrinsic protein activity, allows us to reconstruct in vivo protein function, and this should be an efficient strategy to predict ADMET/efficacy of drug candidates in humans in various disease states. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:3547–3559, 2011 (http://onlinelibrary.wiley.com/doi/10.1002/jps.22612/full)

Samer Aljundi Chem430 F16

2016-09-06T15:25:28Z

Samer Al jundi: /* Research Times */

Chemistry Research 430
:Fall 2016
:Samer Aljundi
:Senior Chemistry Major

==Research Times==
Wed/Thur/Friday 2-5 pm

==Proposed Research Project==
===ADME Research===

===General Information===
:Advisor: Sturgeon, Bradley E

===Proposal===
Still working on it.
===Instruments to be used===
Still working on it.

===Research pledge===
I, Samer Aljundi, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.

Samer Aljundi Chem430 F16

2016-09-06T15:20:36Z

Samer Al jundi: /* Proposed Research Project */

Chemistry Research 430
:Fall 2016
:Samer Aljundi
:Senior Chemistry Major

==Research Times==
Wed/Thur/Friday 2-5 pm

: section 02 = 0.50 credit = 8 hours per week.

==Proposed Research Project==
===ADME Research===

===General Information===
:Advisor: Sturgeon, Bradley E

===Proposal===
Still working on it.
===Instruments to be used===
Still working on it.

===Research pledge===
I, Samer Aljundi, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.

Samer Aljundi Chem430 F16

2016-09-06T15:17:58Z

Samer Al jundi: Created page with "Chemistry Research 430 :Fall 2016 :Samer Aljundi :Senior Chemistry Major ==Research Times== Wed/Thur/Friday 2-5 pm : section 02 = 0.50 credit = 8 hours per week. ==Proposed..."

Chemistry Research 430
:Fall 2016
:Samer Aljundi
:Senior Chemistry Major

==Research Times==
Wed/Thur/Friday 2-5 pm

: section 02 = 0.50 credit = 8 hours per week.

==Proposed Research Project==
===ADME Research===

===General Information===
:Advisor: Sturgeon, Bradley E

===Proposal===
Still working on it.
===Instruments to be used===
Still working on it.
===References (2 minimum)===

===Research pledge===
I, Samer Aljundi, have read the Chem/Bioc 430 course syllabus and understand the general structure and expectations of the research program. The above material was prepared after consultation, and in conjunction with my research advisor.